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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity in the mesolimbic dopamine (DA) circuitry. The importance of drug induced NMDAR mediated adaptations in ventral tegmental area (VTA) DA neurons, and its association with drug seeking behaviors, has recently been evaluated in Cre-loxp mice lacking functional NMDARs in DA neurons expressing Cre recombinase under the control of the endogenous dopamine transporter gene (NR1(DATCre) mice).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:BäckmanCristina MCM,
pubmed-author:CheferVladimir IVI,
pubmed-author:Diaz-RuizOscarO,
pubmed-author:GoodCameron HCH,
pubmed-author:HoffmanAlexander FAF,
pubmed-author:KuangSerena YSY,
pubmed-author:LupicaCarl RCR,
pubmed-author:MalikNasirN,
pubmed-author:NiN SNS,
pubmed-author:ShanLufeiL,
pubmed-author:TomacAndreas CAC,
pubmed-author:ZhangYaJunY
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e12141
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pubmed:meshHeading |
pubmed-meshheading:20808436-Animals,
pubmed-meshheading:20808436-Behavior, Animal,
pubmed-meshheading:20808436-Cocaine,
pubmed-meshheading:20808436-Conditioning (Psychology),
pubmed-meshheading:20808436-Dopamine,
pubmed-meshheading:20808436-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:20808436-Gene Knockout Techniques,
pubmed-meshheading:20808436-Glutamic Acid,
pubmed-meshheading:20808436-Integrases,
pubmed-meshheading:20808436-Mice,
pubmed-meshheading:20808436-Motor Activity,
pubmed-meshheading:20808436-Neurons,
pubmed-meshheading:20808436-Nucleus Accumbens,
pubmed-meshheading:20808436-Olfactory Bulb,
pubmed-meshheading:20808436-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:20808436-Recombination, Genetic,
pubmed-meshheading:20808436-Signal Transduction,
pubmed-meshheading:20808436-Synapses,
pubmed-meshheading:20808436-Ventral Tegmental Area
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pubmed:year |
2010
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pubmed:articleTitle |
NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization.
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pubmed:affiliation |
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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