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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
Adrenaline stimulates biphasic aggregation in plasma through the G(i) -coupled ?(2A) -adrenoreceptor. In the present study, we demonstrate that both primary and secondary wave aggregation induced by adrenaline in plasma is blocked by two structurally distinct inhibitors of Src family kinases, dasatinib and PD0173952.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-(2,6-dichlorophenyl)-10-methyl-3-(...,
http://linkedlifedata.com/resource/pubmed/chemical/Aza Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y12,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/dasatinib,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 International Society on Thrombosis and Haemostasis.
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2273-82
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pubmed:meshHeading |
pubmed-meshheading:20738760-Aza Compounds,
pubmed-meshheading:20738760-Blood Platelets,
pubmed-meshheading:20738760-Cyclic AMP,
pubmed-meshheading:20738760-Epinephrine,
pubmed-meshheading:20738760-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:20738760-Humans,
pubmed-meshheading:20738760-Morpholines,
pubmed-meshheading:20738760-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20738760-Phosphorylation,
pubmed-meshheading:20738760-Platelet Activation,
pubmed-meshheading:20738760-Platelet-Rich Plasma,
pubmed-meshheading:20738760-Protein Kinase Inhibitors,
pubmed-meshheading:20738760-Pyrimidines,
pubmed-meshheading:20738760-Receptors, Purinergic P2Y12,
pubmed-meshheading:20738760-Thiazoles,
pubmed-meshheading:20738760-Tyrosine,
pubmed-meshheading:20738760-src-Family Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Src family kinases are essential for primary aggregation by G(i) -coupled receptors.
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pubmed:affiliation |
Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, UK. can562@bham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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