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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2010-10-13
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pubmed:abstractText |
The MOTIVATE-1 and 2 studies compared maraviroc (MVC) along with optimized background therapy (OBT) vs. placebo along with OBT in treatment-experienced patients screened as having R5-HIV (original Monogram Trofile). A subset screened with non-R5 HIV were treated with MVC or placebo along with OBT in a sister safety trial, A4001029. This analysis retrospectively examined the performance of population-based sequence analysis of HIV-1 env V3-loop to predict coreceptor tropism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1473-5571
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pubmed:author |
pubmed-author:ChapmanDouglassD,
pubmed-author:DongWinnieW,
pubmed-author:HarriganP RichardPR,
pubmed-author:HeeraJayvantJ,
pubmed-author:JamesIanI,
pubmed-author:LewisMarilynM,
pubmed-author:McGovernRachel ARA,
pubmed-author:MoTheresaT,
pubmed-author:ThielenAlexanderA,
pubmed-author:ValdezHernanH,
pubmed-author:WoodsConan KCK
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2517-25
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pubmed:meshHeading |
pubmed-meshheading:20736814-Adult,
pubmed-meshheading:20736814-CD4 Lymphocyte Count,
pubmed-meshheading:20736814-Clinical Trials as Topic,
pubmed-meshheading:20736814-Cyclohexanes,
pubmed-meshheading:20736814-Female,
pubmed-meshheading:20736814-Genotype,
pubmed-meshheading:20736814-HIV Envelope Protein gp120,
pubmed-meshheading:20736814-HIV Infections,
pubmed-meshheading:20736814-HIV-1,
pubmed-meshheading:20736814-Humans,
pubmed-meshheading:20736814-Male,
pubmed-meshheading:20736814-RNA, Viral,
pubmed-meshheading:20736814-Receptors, HIV,
pubmed-meshheading:20736814-Sequence Analysis, DNA,
pubmed-meshheading:20736814-Triazoles,
pubmed-meshheading:20736814-Viral Load,
pubmed-meshheading:20736814-Viral Tropism
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pubmed:year |
2010
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pubmed:articleTitle |
Population-based V3 genotypic tropism assay: a retrospective analysis using screening samples from the A4001029 and MOTIVATE studies.
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pubmed:affiliation |
BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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