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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-8-24
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pubmed:abstractText |
It was established that in a mononuclear fraction polyoxidonium inhibited the TNF-alpha production and stimulated the IL-1 beta and IL-6 production. In LPS-induced mononuclear cultures polyoxidonium inhibited the IL-6 production and had no statistically significant effect on the synthesis of TNF-alpha and IL-1 beta. Polyoxidonium had no effect on TNF-alpha, IL-6 and IL-1 beta production by purified monocytes. The addition of polyoxidonium with dexamethasone to the cultures only in monocyte fraction enhanced the IL-1 beta production as compared with the effect of dexamethasone alone. Data obtained allow suggesting that under certain conditions polyoxidonium could alleviate pronounced suppressive influence of glucocorticoids on a secretory activity of effectors of innate immunity.
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pubmed:language |
rus
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0031-2991
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-3
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pubmed:meshHeading |
pubmed-meshheading:20731121-Adult,
pubmed-meshheading:20731121-Anti-Inflammatory Agents,
pubmed-meshheading:20731121-Dexamethasone,
pubmed-meshheading:20731121-Drug Synergism,
pubmed-meshheading:20731121-Female,
pubmed-meshheading:20731121-Humans,
pubmed-meshheading:20731121-Interleukin-1beta,
pubmed-meshheading:20731121-Interleukin-6,
pubmed-meshheading:20731121-Male,
pubmed-meshheading:20731121-Monocytes,
pubmed-meshheading:20731121-Piperazines,
pubmed-meshheading:20731121-Polymers,
pubmed-meshheading:20731121-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
[Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect].
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pubmed:publicationType |
Journal Article,
English Abstract
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