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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BeiskeKlausK,
pubmed-author:CaronHuibH,
pubmed-author:CoolsJanJ,
pubmed-author:De BrouwerSaraS,
pubmed-author:De PaepeAnneA,
pubmed-author:De PreterKatleenK,
pubmed-author:DelattreOlivierO,
pubmed-author:EggertAngelikaA,
pubmed-author:HoebeeckJasmienJ,
pubmed-author:Janoueix-LeroseyIsabelleI,
pubmed-author:KognerPerP,
pubmed-author:KumpsCandyC,
pubmed-author:LakemanArjanA,
pubmed-author:LaureysGenevièveG,
pubmed-author:MartinssonTommyT,
pubmed-author:NakagawaraAkiraA,
pubmed-author:NogueraRosaR,
pubmed-author:OhiraMikiM,
pubmed-author:PorcuMichaëlM,
pubmed-author:RenardMarleenM,
pubmed-author:SchrammAlexanderA,
pubmed-author:SchulteJohannes HJH,
pubmed-author:SpelemanFrankF,
pubmed-author:Van Den BroeckeCarolineC,
pubmed-author:Van MaerkenTomT,
pubmed-author:Van RoyNadineN,
pubmed-author:VandesompeleJoJ,
pubmed-author:VermeulenJoëlleJ,
pubmed-author:VersteegRogierR,
pubmed-author:WesterhoutEllen MEM,
pubmed-author:ZabrockiPiotrP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4353-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20719933-Amino Acid Substitution,
pubmed-meshheading:20719933-Animals,
pubmed-meshheading:20719933-Cell Line, Transformed,
pubmed-meshheading:20719933-Cell Line, Tumor,
pubmed-meshheading:20719933-Cell Transformation, Neoplastic,
pubmed-meshheading:20719933-Gene Amplification,
pubmed-meshheading:20719933-Gene Expression Profiling,
pubmed-meshheading:20719933-Gene Frequency,
pubmed-meshheading:20719933-Humans,
pubmed-meshheading:20719933-Kaplan-Meier Estimate,
pubmed-meshheading:20719933-Mutation,
pubmed-meshheading:20719933-Neuroblastoma,
pubmed-meshheading:20719933-Nuclear Proteins,
pubmed-meshheading:20719933-Oncogene Proteins,
pubmed-meshheading:20719933-Phosphorylation,
pubmed-meshheading:20719933-Protein-Tyrosine Kinases,
pubmed-meshheading:20719933-Receptor Protein-Tyrosine Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.
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pubmed:affiliation |
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
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