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rdf:type |
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lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0031809,
umls-concept:C0033684,
umls-concept:C0035696,
umls-concept:C0040300,
umls-concept:C0052850,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0441889,
umls-concept:C0534522,
umls-concept:C1709450,
umls-concept:C1880287,
umls-concept:C2348042,
umls-concept:C2911684
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pubmed:dateCreated |
2010-9-3
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pubmed:abstractText |
Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in human lung cancer and their potential to serve as molecular markers for early diagnosis remain issues of intense investigation. The main objective of the present study was to use paired tumour/non-tumour biopsies from patients with non-small cell lung cancer (NSCLC) to investigate the expression profiles of hnRNP A1, A2/B1 and A3 in conjunction with ASF/SF2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434
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pubmed:meshHeading |
pubmed-meshheading:20716340-Adenocarcinoma,
pubmed-meshheading:20716340-Adenocarcinoma, Bronchiolo-Alveolar,
pubmed-meshheading:20716340-Aged,
pubmed-meshheading:20716340-Blotting, Western,
pubmed-meshheading:20716340-Carcinoma, Large Cell,
pubmed-meshheading:20716340-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:20716340-Carcinoma, Squamous Cell,
pubmed-meshheading:20716340-Female,
pubmed-meshheading:20716340-Heterogeneous-Nuclear Ribonucleoprotein Group A-B,
pubmed-meshheading:20716340-Humans,
pubmed-meshheading:20716340-Immunoenzyme Techniques,
pubmed-meshheading:20716340-Lung,
pubmed-meshheading:20716340-Lung Neoplasms,
pubmed-meshheading:20716340-Lymphatic Metastasis,
pubmed-meshheading:20716340-Male,
pubmed-meshheading:20716340-Middle Aged,
pubmed-meshheading:20716340-Neoplasm Staging,
pubmed-meshheading:20716340-Nuclear Proteins,
pubmed-meshheading:20716340-RNA, Messenger,
pubmed-meshheading:20716340-RNA-Binding Proteins,
pubmed-meshheading:20716340-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20716340-Survival Rate,
pubmed-meshheading:20716340-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
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pubmed:affiliation |
RNA Processing Program, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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