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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-17
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pubmed:abstractText |
Patients with metastatic colorectal carcinoma (mCRC) carrying activating mutations of the KRAS gene do not benefit from treatment with anti-EGF receptor monoclonal antibodies. Therefore, KRAS mutation testing of mCRC patients is mandatory in the clinical setting to aid in the choice of appropriate therapy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1744-8042
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1169-79
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pubmed:dateRevised |
2011-5-12
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pubmed:meshHeading |
pubmed-meshheading:20712532-Adenocarcinoma,
pubmed-meshheading:20712532-Cohort Studies,
pubmed-meshheading:20712532-Colorectal Neoplasms,
pubmed-meshheading:20712532-Humans,
pubmed-meshheading:20712532-Mutation,
pubmed-meshheading:20712532-Neoplasm Metastasis,
pubmed-meshheading:20712532-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20712532-Proto-Oncogene Proteins,
pubmed-meshheading:20712532-Reproducibility of Results,
pubmed-meshheading:20712532-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20712532-Sensitivity and Specificity,
pubmed-meshheading:20712532-ras Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach.
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pubmed:affiliation |
Pharmacogenomic Laboratory, Centro Ricerche Oncologiche di Mercogliano, Avellino, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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