|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2010-8-10
|
|
pubmed:abstractText |
The B cell antigen receptor (BCR) plays an essential role in all phases of B cell development. Here we show that the extracellular domains of murine and human Igbeta form an I-set immunoglobulin-like structure with an interchain disulfide between cysteines on their G strands. Structural and sequence analysis suggests that Igalpha displays a similar fold as Igbeta. An Igalphabeta heterodimer model was generated based on the unique disulfide-bonded Igbeta dimer. Solution binding studies showed that the extracellular domains of Igalphabeta preferentially recognize the constant region of BCR with mu chain specificity, suggesting a role for Igalphabeta to enhance BCRmu chain signaling. Cluster mutations on Igalpha, Igbeta, and a membrane-bound form of immunoglobulin (mIgM) based on the structural model identified distinct areas of potential contacts involving charged residues on both subunits of the coreceptor and the Cmu4 domain of mIgM. These studies provide the first structural model for understanding BCR function.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-10090943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-10533318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-10933390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-11052947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-11279501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-11578689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-12040177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-12115635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-12507424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-12768205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-12886015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-1448155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-14656437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15219998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15299704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-1547508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15572765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15696168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15771571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15771577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-1591006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-15983406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-16200067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-16239921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-16473826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-16877534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-16895553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-17675166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-18488311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-1881434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-2023945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-2304550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-2358676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-2927501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-3137575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-3289580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-7020376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-7533164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-7561018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-7794818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-7807000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8144885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8176743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8177320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8245014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8262964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8290550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8657279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-8906788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-9571064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20696394-9757107
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1878-4186
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
11
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
934-43
|
|
pubmed:dateRevised |
2011-8-12
|
|
pubmed:meshHeading |
|
