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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0030705,
umls-concept:C0068355,
umls-concept:C0086597,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0225360,
umls-concept:C1417771,
umls-concept:C1511938,
umls-concept:C1800706,
umls-concept:C2709248,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-5
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pubmed:abstractText |
Persistence of myofibroblasts is believed to contribute to the development of fibrosis in idiopathic pulmonary fibrosis (IPF). Transforming growth factor beta1 (TGFbeta1) irreversibly converts fibroblasts into pathological myofibroblasts, which express smooth muscle alpha-actin (alpha-SMA) and produce extracellular matrix proteins, such as procollagen I (alpha1). Reactive oxygen species produced by NADPH oxidases (NOXs) have been shown to regulate cell differentiation. It was hypothesised that NOX could be expressed in parenchymal pulmonary fibroblasts and could mediate TGFbeta1-stimulated conversion of fibroblasts into myofibroblasts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/NOX4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1468-3296
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-8
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pubmed:dateRevised |
2010-12-21
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pubmed:meshHeading |
pubmed-meshheading:20685750-Adult,
pubmed-meshheading:20685750-Aged,
pubmed-meshheading:20685750-Cell Differentiation,
pubmed-meshheading:20685750-Cells, Cultured,
pubmed-meshheading:20685750-Female,
pubmed-meshheading:20685750-Fibroblasts,
pubmed-meshheading:20685750-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20685750-Humans,
pubmed-meshheading:20685750-Idiopathic Pulmonary Fibrosis,
pubmed-meshheading:20685750-Lung,
pubmed-meshheading:20685750-Male,
pubmed-meshheading:20685750-Middle Aged,
pubmed-meshheading:20685750-NADPH Oxidase,
pubmed-meshheading:20685750-Platelet-Derived Growth Factor,
pubmed-meshheading:20685750-RNA, Messenger,
pubmed-meshheading:20685750-Reactive Oxygen Species,
pubmed-meshheading:20685750-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20685750-Smad2 Protein,
pubmed-meshheading:20685750-Smad3 Protein,
pubmed-meshheading:20685750-Transforming Growth Factor beta1,
pubmed-meshheading:20685750-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts.
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pubmed:affiliation |
INSERM, Unité 700, Université Paris 7 Denis Diderot, site Bichat, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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