Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
|
pubmed:dateCreated |
1991-8-14
|
pubmed:abstractText |
4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 microM. An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives. The corresponding thiazolidin-4-one analogues were found to be relatively inactive. The 4-hydroxythiazoles were active inhibitors against 5-lipoxygenase in both intact rat polymorphonuclear leukocytes and human whole blood. The compounds were also selective inhibitors of 5-lipoxygenase, displaying only weak activity against other related enzymes, cyclooxygenase and 12- and 15-lipoxygenase.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2158-65
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:2066989-Animals,
pubmed-meshheading:2066989-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:2066989-Chemical Phenomena,
pubmed-meshheading:2066989-Chemistry,
pubmed-meshheading:2066989-Enzyme Inhibitors,
pubmed-meshheading:2066989-Humans,
pubmed-meshheading:2066989-Lipoxygenase Inhibitors,
pubmed-meshheading:2066989-Male,
pubmed-meshheading:2066989-Rats,
pubmed-meshheading:2066989-Rats, Inbred Strains,
pubmed-meshheading:2066989-Structure-Activity Relationship,
pubmed-meshheading:2066989-Thiazoles
|
pubmed:year |
1991
|
pubmed:articleTitle |
4-hydroxythiazole inhibitors of 5-lipoxygenase.
|
pubmed:affiliation |
Immunosciences Research Area, Abbott Laboratories, Abbott Park, Illinois 60064.
|
pubmed:publicationType |
Journal Article
|