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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-8-27
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pubmed:abstractText |
Status epilepticus (SE) leads to upregulation of pro-inflammatory proteins including cyclooxygenase-2 (cox-2) which could be implicated in the epileptogenic process and epileptic seizures. Recent studies show that cox-2 can regulate expression of P-glycoprotein (P-gp) during epileptogenesis and epilepsy. P-gp could cause pharmacoresistance by reducing brain entry of anti-epileptic drugs such as phenytoin (PHT). Here we have investigated the effects of cox-2 inhibition on epileptogenesis, spontaneous seizures and PHT treatment in a rat model for temporal lobe epilepsy (TLE).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1872-6844
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-56
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pubmed:meshHeading |
pubmed-meshheading:20643531-Animals,
pubmed-meshheading:20643531-Chronic Disease,
pubmed-meshheading:20643531-Cyclooxygenase 2,
pubmed-meshheading:20643531-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:20643531-Disease Models, Animal,
pubmed-meshheading:20643531-Electroencephalography,
pubmed-meshheading:20643531-Epilepsy, Temporal Lobe,
pubmed-meshheading:20643531-Male,
pubmed-meshheading:20643531-Pyrazoles,
pubmed-meshheading:20643531-Rats,
pubmed-meshheading:20643531-Rats, Sprague-Dawley,
pubmed-meshheading:20643531-Sulfonamides
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pubmed:year |
2010
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pubmed:articleTitle |
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy.
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pubmed:affiliation |
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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