Linked Life Data

20623690

Source:http://linkedlifedata.com/resource/pubmed/id/20623690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2010-11-11
pubmed:abstractText
Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA-C) and parkinsonian variants of MSA (MSA-P) are distinguished. We investigated 14 MSA patients (10 MSA-C, 4 MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel-based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow-up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue-loss profiles (i.e., baseline versus follow-up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto-cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow-up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow-up. This was replicated through additional shape-based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease-specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000865, http://linkedlifedata.com/resource/pubmed/grant/P41 RR013642, http://linkedlifedata.com/resource/pubmed/grant/P41 RR013642-02, http://linkedlifedata.com/resource/pubmed/grant/R01 AG020098, http://linkedlifedata.com/resource/pubmed/grant/R01 EB007813, http://linkedlifedata.com/resource/pubmed/grant/R01 EB007813-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 EB008281, http://linkedlifedata.com/resource/pubmed/grant/R01 EB008281-11A1, http://linkedlifedata.com/resource/pubmed/grant/R01 EB008432, http://linkedlifedata.com/resource/pubmed/grant/R01 EB008432-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 HD050735, http://linkedlifedata.com/resource/pubmed/grant/U54 RR021813, http://linkedlifedata.com/resource/pubmed/grant/U54 RR021813-01
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1531-8257
pubmed:author
pubmed:copyrightInfo
© 2010 Movement Disorder Society.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2613-20
pubmed:dateRevised
2011-10-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Callosal tissue loss in multiple system atrophy--a one-year follow-up study.
pubmed:affiliation
Institute of Neurosciences and Medicine-1, Research Centre Jülich, Jülich, Germany. m.minnerop@fz-juelich.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural