Linked Life Data

20604710

Source:http://linkedlifedata.com/resource/pubmed/id/20604710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-8
pubmed:abstractText
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases consists of at least 60 different substrates. γ-Secretase is key to regulated intramembrane proteolysis, releasing protein fragments that potentially transduce signals at both sides of the cell membrane. Characteristic for this novel form of cellular signaling is its irreversible nature, providing direction to biological processes. We discuss recent insights in structure-function and assembly of the γ-secretase complexes and emerging insights in the regulation of the activity of these enzymes. This novel knowledge will help to develop better drugs for Alzheimer's disease and cancer. We critically evaluate literature that proposes presenilin functions outside of the γ-secretase complex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1530-8995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-60
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Novel research horizons for presenilins and ?-secretases in cell biology and disease.
pubmed:affiliation
Center for Human Genetics, Katholieke Universiteit Leuven, and Department for Molecular and Developmental Genetics, VIB, Leuven, Belgium. Bart.destrooper@cme.vib-kuleuven.be
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't