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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-2
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pubmed:abstractText |
Wilson disease is a genetic disorder associated with copper overload due to mutations within the ATP7B gene. Although copper and iron metabolism are closely linked, the influence of mutations of the ATP7B gene on iron homeostasis is unknown. Therefore, the present study was carried out to elucidate iron metabolism in Atp7b(-/-) mice, an animal model of Wilson disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1440-1746
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1144-50
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pubmed:meshHeading |
pubmed-meshheading:20594231-Adenosine Triphosphatases,
pubmed-meshheading:20594231-Animals,
pubmed-meshheading:20594231-Blotting, Western,
pubmed-meshheading:20594231-Cation Transport Proteins,
pubmed-meshheading:20594231-Ceruloplasmin,
pubmed-meshheading:20594231-Copper,
pubmed-meshheading:20594231-DNA,
pubmed-meshheading:20594231-Disease Models, Animal,
pubmed-meshheading:20594231-Disease Progression,
pubmed-meshheading:20594231-Duodenum,
pubmed-meshheading:20594231-Gene Expression Regulation,
pubmed-meshheading:20594231-Hepatolenticular Degeneration,
pubmed-meshheading:20594231-Iron,
pubmed-meshheading:20594231-Liver,
pubmed-meshheading:20594231-Mice,
pubmed-meshheading:20594231-Mice, Knockout,
pubmed-meshheading:20594231-Phenotype,
pubmed-meshheading:20594231-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Evidence for a critical role of ceruloplasmin oxidase activity in iron metabolism of Wilson disease gene knockout mice.
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pubmed:affiliation |
Department of Gastroenterology, University Hospital, Heidelberg, Germany. uta_merle@med.uni-heidelberg.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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