|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-6-24
|
|
pubmed:abstractText |
MicroRNAs (miRNAs) are a class of short non-coding RNAs that regulate cell homeostasis by inhibiting translation or degrading mRNA of target genes, and thereby can act as tumor suppressor genes or oncogenes. The role of microRNAs in medulloblastoma has only recently been addressed. We hypothesized that microRNAs differentially expressed during normal CNS development might be abnormally regulated in medulloblastoma and are functionally important for medulloblastoma cell growth.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-10080536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-11283316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-12150819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-14574365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15003116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15029199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15372042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15549107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15649818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15774722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15806104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15811427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15853514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15908947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15944707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15944708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-15964994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-16110011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-16224044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-16567768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-16641092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-17329407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-17401365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-17597110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-17612493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-17908999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-18282568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-18577219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-18607543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-18973228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-19010882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-19194462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-19196975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-19351822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-19404261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-6095281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-8622687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20574517-9923679
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e10748
|
|
pubmed:meshHeading |
pubmed-meshheading:20574517-Base Sequence,
pubmed-meshheading:20574517-Brain,
pubmed-meshheading:20574517-Cell Aging,
pubmed-meshheading:20574517-Cell Line, Tumor,
pubmed-meshheading:20574517-Cell Proliferation,
pubmed-meshheading:20574517-Down-Regulation,
pubmed-meshheading:20574517-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20574517-Humans,
pubmed-meshheading:20574517-Intracellular Space,
pubmed-meshheading:20574517-Medulloblastoma,
pubmed-meshheading:20574517-MicroRNAs,
pubmed-meshheading:20574517-Nuclear Proteins,
pubmed-meshheading:20574517-Proto-Oncogene Proteins,
pubmed-meshheading:20574517-Reactive Oxygen Species,
pubmed-meshheading:20574517-Repressor Proteins,
pubmed-meshheading:20574517-Signal Transduction,
pubmed-meshheading:20574517-Superoxides
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence.
|
|
pubmed:affiliation |
Department of Pediatrics, University of Colorado, Denver, Colorado, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
