Source:http://linkedlifedata.com/resource/pubmed/id/20562654
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rdf:type | |
lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0017262,
umls-concept:C0021756,
umls-concept:C0034819,
umls-concept:C0040300,
umls-concept:C0079731,
umls-concept:C0185117,
umls-concept:C1101536,
umls-concept:C1149197,
umls-concept:C1334114,
umls-concept:C1516606,
umls-concept:C1707520,
umls-concept:C2003941,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2010-8-6
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pubmed:abstractText |
SUMMARY: The study aimed at analysis of tissue expression of interleukin 2 (IL-2) and subunit alpha of its receptor (IL-22R(alpha)/CD25) in B-cell non-Hodgkin lymphomas (B-cell NHLs) in children as related to selected clinical data. The studies were performed on an archival tissue material originating from children with B-cell NHLs (n=26) using avidin-biotin-peroxidase complex method and in-situ hybridization with biotinylated tyramine amplification signal (ImmunoMax technique). As compared with non-neoplastic lesions, in B-cell NHLs a significantly higher expression was noted of both IL-2 and IL-22R(alpha). In children with B-cell NHLs, frequency of IL-2 detection was 62%, and that of IL-22R(alpha), 46%. Using hybridocytochemistry, presence of mRNA for IL-2 could be detected, but not mRNA for IL-22R(alpha) in children with B-cell NHLs. A significant direct relationship was demonstrated between expressions of IL-2 and IL-22R(alpha) in children with B-cell NHLs. No significant relationships could be detected between expression of IL-2 and/or IL-22R(alpha) on one hand and histopathologic diagnosis, tumor location, age, or sex in B-cell NHLs on the other. The new element in the results involved demonstration of significant differences in shorter survival of children with B-cell NHLs, as related to cellular expression of IL-2 and IL-22R(alpha) (CD25). Comparing the expected percentage of patients at risk, children with CD25-positive tissue expression had a significantly lower chance to survive longer time than children with IL-2-positive tissue expression. The positive relationship between tissue expression of IL-22R(alpha) and the shorter survival of children with B-cell NHLs should prompt further investigations to identify other risk factors in patients with this type of tumors in children.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1536-3678
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
462-71
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pubmed:dateRevised |
2011-10-6
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pubmed:meshHeading |
pubmed-meshheading:20562654-Adolescent,
pubmed-meshheading:20562654-Child,
pubmed-meshheading:20562654-Child, Preschool,
pubmed-meshheading:20562654-Female,
pubmed-meshheading:20562654-Humans,
pubmed-meshheading:20562654-Immunohistochemistry,
pubmed-meshheading:20562654-In Situ Hybridization,
pubmed-meshheading:20562654-Infant,
pubmed-meshheading:20562654-Interleukin-2,
pubmed-meshheading:20562654-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:20562654-Kaplan-Meier Estimate,
pubmed-meshheading:20562654-Lymphoma, B-Cell,
pubmed-meshheading:20562654-Male,
pubmed-meshheading:20562654-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Tissue expression of interleukin 2 (IL-2) and IL-2 receptor (IL-2R(alpha)/CD25) in non-Hodgkin B-cell lymphomas in children: correlations with clinical data.
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pubmed:affiliation |
Department of Histology and Embryology, Poznan University of Medical Sciences, Pozna?, Poland. akasprza@ump.edu.pl
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pubmed:publicationType |
Journal Article
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