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rdf:type |
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lifeskim:mentions |
umls-concept:C0020517,
umls-concept:C0021469,
umls-concept:C0024880,
umls-concept:C0031715,
umls-concept:C0079904,
umls-concept:C0086418,
umls-concept:C0086982,
umls-concept:C0109317,
umls-concept:C0599779,
umls-concept:C0752312,
umls-concept:C1011804,
umls-concept:C1150579,
umls-concept:C1280500,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1527304,
umls-concept:C1705767,
umls-concept:C1705791
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-28
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pubmed:abstractText |
The root cortex of Paeonia suffruticosa Andrews (PSA), also known as Moutan Cortex, is known to have anti-allergic and anti-inflammatory properties. This study investigates the effect and mechanism of PSA by in vivo and in vitro methods. Treatings the root cortex from PSA with up to 0.4 mg/ml of an ethanol extract showed no cytotoxicity in human mast cells. The ethanol extract of PSA (200 mg/kg) significantly inhibited the passive cutaneous anaphylaxis reaction in vivo, and suppressed the release of histamine from rat peritoneal mast cells induced by compound 48/80. It was also found that PSA decreased the expressions of TNF-alpha and IL-6 in PMA- and A23187-stimulated HMC-1 cells. The results show the inactivation of I kappaB-alpha and NF-kappaB, as well as suppression of the phosphorylation of extracellular signal-regulated kinase (ERK). Our findings therefore suggest that PSA could be promising for anti-allergic inflammation by inhibiting the NF-kappaB/I kappaB-alpha signaling pathway and the phosphorylation of ERK.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1347-6947
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1152-6
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pubmed:dateRevised |
2010-12-28
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pubmed:meshHeading |
pubmed-meshheading:20530912-Animals,
pubmed-meshheading:20530912-Anti-Inflammatory Agents,
pubmed-meshheading:20530912-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:20530912-Histamine Release,
pubmed-meshheading:20530912-Humans,
pubmed-meshheading:20530912-Hypersensitivity,
pubmed-meshheading:20530912-I-kappa B Proteins,
pubmed-meshheading:20530912-Immunoglobulin E,
pubmed-meshheading:20530912-Interleukin-6,
pubmed-meshheading:20530912-Male,
pubmed-meshheading:20530912-Mast Cells,
pubmed-meshheading:20530912-Models, Animal,
pubmed-meshheading:20530912-NF-kappa B,
pubmed-meshheading:20530912-Paeonia,
pubmed-meshheading:20530912-Phosphorylation,
pubmed-meshheading:20530912-Plant Extracts,
pubmed-meshheading:20530912-Rats,
pubmed-meshheading:20530912-Rats, Sprague-Dawley,
pubmed-meshheading:20530912-Signal Transduction,
pubmed-meshheading:20530912-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibitory effects of Paeonia suffruticosa on allergic reactions by inhibiting the NF-kappaB/I kappaB-alpha signaling pathway and phosphorylation of ERK in an animal model and human mast cells.
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pubmed:affiliation |
Department of Preventive Medicine, College of Korean Medicine, Kyunghee University, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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