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rdf:type |
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lifeskim:mentions |
umls-concept:C0028798,
umls-concept:C0040905,
umls-concept:C0054950,
umls-concept:C0079720,
umls-concept:C0332157,
umls-concept:C0332281,
umls-concept:C1304884,
umls-concept:C1456796,
umls-concept:C1705984,
umls-concept:C1749467,
umls-concept:C1824668,
umls-concept:C2745888
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pubmed:issue |
9
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
Occupational cohort and case-control studies suggest that trichloroethylene (TCE) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings are not consistent. There is a need for mechanistic studies to evaluate the biologic plausibility of this association. We carried out a cross-sectional molecular epidemiology study of 80 healthy workers that used TCE and 96 comparable unexposed controls in Guangdong, China. Personal exposure measurements were taken over a three-week period before blood collection. Ninety-six percent of workers were exposed to TCE below the current US Occupational Safety and Health Administration Permissible Exposure Limit (100 p.p.m. 8 h time-weighted average), with a mean (SD) of 22.2 (36.0) p.p.m. The total lymphocyte count and each of the major lymphocyte subsets including CD4+ T cells, CD8+ T cells, natural killer (NK) cells and B cells were significantly decreased among the TCE-exposed workers compared with controls (P < 0.05), with evidence of a dose-dependent decline. Further, there was a striking 61% decline in sCD27 plasma level and a 34% decline in sCD30 plasma level among TCE-exposed workers compared with controls. This is the first report that TCE exposure under the current Occupational Safety and Health Administration workplace standard is associated with a decline in all major lymphocyte subsets and sCD27 and sCD30, which play an important role in regulating cellular activity in subsets of T, B and NK cells and are associated with lymphocyte activation. Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-10807550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-10807565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-11966765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-12221457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-14551032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-14652303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-15501392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-15576619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-15770006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-15891523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-16284097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-16338493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-1659587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-16966107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-17190186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-17337643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-18223013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19001957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19332086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19426224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19479009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19647757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19710474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19772921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-19890498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-7482570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-7641505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20530238-8933028
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1460-2180
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pubmed:author |
pubmed-author:Beane FreemanLaura ELE,
pubmed-author:BlairAaron EAE,
pubmed-author:GalvãoD ADA,
pubmed-author:GeYichenY,
pubmed-author:GuoWeihongW,
pubmed-author:HaggD DDD,
pubmed-author:HaoZhenyueZ,
pubmed-author:HuangHanlinH,
pubmed-author:JiZhiyingZ,
pubmed-author:LanQingQ,
pubmed-author:LiLaiyuL,
pubmed-author:LiuSongwangS,
pubmed-author:PurdueMark PMP,
pubmed-author:QiuChuangyiC,
pubmed-author:ReissBorisB,
pubmed-author:RothmanNathanielN,
pubmed-author:ShenMinM,
pubmed-author:SmithMartyn TMT,
pubmed-author:TangXiaojiangX,
pubmed-author:VermeulenRoelR,
pubmed-author:XieYuxuanY,
pubmed-author:XinKerry XKX,
pubmed-author:XiongJunJ,
pubmed-author:YaoQQ,
pubmed-author:ZhangLuopingL
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1592-6
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pubmed:dateRevised |
2011-9-13
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pubmed:meshHeading |
pubmed-meshheading:20530238-Antigens, CD27,
pubmed-meshheading:20530238-Antigens, CD30,
pubmed-meshheading:20530238-Biological Markers,
pubmed-meshheading:20530238-Case-Control Studies,
pubmed-meshheading:20530238-Humans,
pubmed-meshheading:20530238-Lymphocyte Count,
pubmed-meshheading:20530238-Lymphocyte Subsets,
pubmed-meshheading:20530238-Molecular Epidemiology,
pubmed-meshheading:20530238-Occupational Exposure,
pubmed-meshheading:20530238-Trichloroethylene
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pubmed:year |
2010
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pubmed:articleTitle |
Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers.
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pubmed:affiliation |
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA. qingl@mail.nih.gov
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