Source:http://linkedlifedata.com/resource/umls/id/C0054950
MSH: A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.,NCI: Expressed in activated T- and B-cells by human TNFRSF8 Gene (TNFR Superfamily) as distinct serine and tyrosine phosphorylated Long (595-aa, 64-kDa precursor type I membrane protein) and Short (cytoplasmic) isoforms, TNF Receptor 8 contains 6 TNFR-Cys repeats. A positive regulator of apoptosis and receptor for TNFSF8/CD30L, TNFRSF8 interacts with the TRAF1, TRAF2, TRAF3, and TRAF5 mediators of signal transduction and regulates gene expression through NF-Kappa-B activation. A Hodgkin's disease associated antigen, TNFRSF8 limits the proliferative potenti