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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2010-6-22
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pubmed:abstractText |
Coxsackievirus B3 infection is an excellent model of human myocarditis and dilated cardiomyopathy. Cardiac injury is caused either by a direct cytopathic effect of the virus or through immune-mediated mechanisms. Regulatory T cells (Tregs) play an important role in the negative modulation of host immune responses and set the threshold of autoimmune activation. This study was designed to test the protective effects of Tregs and to determine the underlying mechanisms.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2624-34
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20530002-Adaptive Immunity,
pubmed-meshheading:20530002-Animals,
pubmed-meshheading:20530002-Cells, Cultured,
pubmed-meshheading:20530002-Disease Models, Animal,
pubmed-meshheading:20530002-Enterovirus B, Human,
pubmed-meshheading:20530002-Kaplan-Meier Estimate,
pubmed-meshheading:20530002-Mice,
pubmed-meshheading:20530002-Mice, Inbred C57BL,
pubmed-meshheading:20530002-Myocarditis,
pubmed-meshheading:20530002-Myocytes, Cardiac,
pubmed-meshheading:20530002-Phosphorylation,
pubmed-meshheading:20530002-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20530002-Rats,
pubmed-meshheading:20530002-Rats, Sprague-Dawley,
pubmed-meshheading:20530002-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:20530002-T-Lymphocytes, Regulatory,
pubmed-meshheading:20530002-Transforming Growth Factor beta,
pubmed-meshheading:20530002-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway.
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pubmed:affiliation |
Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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