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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-23
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pubmed:abstractText |
A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:DuYongliY,
pubmed-author:HuDingyuD,
pubmed-author:HuiXinX,
pubmed-author:LiQunyiQ,
pubmed-author:MengTaoT,
pubmed-author:ShenJingkangJ,
pubmed-author:VigoC BCB,
pubmed-author:WangMingweiM,
pubmed-author:XiongBingB,
pubmed-author:YangFengF,
pubmed-author:ZhangDatongD
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pubmed:copyrightInfo |
Copyright 2010. Published by Elsevier Ltd.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4255-68
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pubmed:meshHeading |
pubmed-meshheading:20510622-Aniline Compounds,
pubmed-meshheading:20510622-Animals,
pubmed-meshheading:20510622-Binding Sites,
pubmed-meshheading:20510622-Chalcones,
pubmed-meshheading:20510622-Computer Simulation,
pubmed-meshheading:20510622-Crystallography, X-Ray,
pubmed-meshheading:20510622-Humans,
pubmed-meshheading:20510622-Ketones,
pubmed-meshheading:20510622-Ligands,
pubmed-meshheading:20510622-Mice,
pubmed-meshheading:20510622-Molecular Conformation,
pubmed-meshheading:20510622-Protein Binding,
pubmed-meshheading:20510622-Receptors, Progesterone,
pubmed-meshheading:20510622-Stereoisomerism,
pubmed-meshheading:20510622-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.
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pubmed:affiliation |
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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