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pubmed-article:20506089pubmed:abstractTextWe created a registry to evaluate long term outcome, efficacy and adverse events for children treated wit TNF-alpha inhibitors in Switzerland. 106 patients (68 female/38 male) were included. 61 patients were treated with Etanercept (Enbrel) and 45 with Infliximab (Remicade). Concomitant treatment at baseline included corticosteroids in 26% and Methotrexate in 75% of the patients. Subjective disease activity three months after initiation of TNF-alpha was better in 81%, worse in 4% and stable in 15% of the patients. In total 24 adverse events in 21 patients were reported. Treatment with TNF-alpha inhibitors seems to be safe and effective for children and adolescents with rheumatologic diseases.lld:pubmed
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pubmed-article:20506089pubmed:articleTitle[Swiss registry for TNF-alpha blockers in children and adolescents with rheumatological diseases].lld:pubmed
pubmed-article:20506089pubmed:affiliationUnikinderklinik für Kinderheilkunde+Uniklinik für Rheumatologie, Klinische Immunologie+Allergologie, Inselspital, Universitätsspital Bern.lld:pubmed
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