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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
11
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pubmed:dateCreated |
2010-5-27
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|
pubmed:abstractText |
We created a registry to evaluate long term outcome, efficacy and adverse events for children treated wit TNF-alpha inhibitors in Switzerland. 106 patients (68 female/38 male) were included. 61 patients were treated with Etanercept (Enbrel) and 45 with Infliximab (Remicade). Concomitant treatment at baseline included corticosteroids in 26% and Methotrexate in 75% of the patients. Subjective disease activity three months after initiation of TNF-alpha was better in 81%, worse in 4% and stable in 15% of the patients. In total 24 adverse events in 21 patients were reported. Treatment with TNF-alpha inhibitors seems to be safe and effective for children and adolescents with rheumatologic diseases.
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pubmed:language |
ger
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
May
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|
pubmed:issn |
1661-8157
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-54
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pubmed:meshHeading |
pubmed-meshheading:20506089-Adolescent,
pubmed-meshheading:20506089-Adverse Drug Reaction Reporting Systems,
pubmed-meshheading:20506089-Antibodies, Monoclonal,
pubmed-meshheading:20506089-Antirheumatic Agents,
pubmed-meshheading:20506089-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:20506089-Child,
pubmed-meshheading:20506089-Drug Interactions,
pubmed-meshheading:20506089-Drug Therapy, Combination,
pubmed-meshheading:20506089-Humans,
pubmed-meshheading:20506089-Immunoglobulin G,
pubmed-meshheading:20506089-Product Surveillance, Postmarketing,
pubmed-meshheading:20506089-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:20506089-Registries,
pubmed-meshheading:20506089-Rheumatic Diseases,
pubmed-meshheading:20506089-Switzerland,
pubmed-meshheading:20506089-Treatment Outcome,
pubmed-meshheading:20506089-Tumor Necrosis Factor-alpha,
pubmed-meshheading:20506089-Uveitis
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
[Swiss registry for TNF-alpha blockers in children and adolescents with rheumatological diseases].
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|
pubmed:affiliation |
Unikinderklinik für Kinderheilkunde+Uniklinik für Rheumatologie, Klinische Immunologie+Allergologie, Inselspital, Universitätsspital Bern.
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pubmed:publicationType |
Journal Article,
English Abstract
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