Linked Life Data

20499205

Source:http://linkedlifedata.com/resource/pubmed/id/20499205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2011-5-18
pubmed:abstractText
The distribution of Cd (II) and Pb (II) among amino acids in parenteral nutrition formulations was investigated by coupling ion-chromatography (HPLC/IC) and electrothermal atomic absorption spectrometry. The methodology was based on ion-exchange separation and fluorimetric amino acid detection after post-column derivatization. Cd (II) and Pb (II) were assayed in 500-µL fractions of the column effluent. The distribution of Cd (II) and Pb (II) in alanine (Ala), aspartic acid (Asp), glutamic acid (Glu), glycine (Gly), histidine (His), methionine (Met), phenylalanine (Phe), serine (Ser), and threonine (Thr) were analyzed by monitoring changes in the concentration of free amino acids by HPLC/IC. The results indicated that Cd (II) and Pb (II) were distributed according to the following trend: Gly-Cd?>?Gly-Pb?>?Ala-Cd?>?Ala-Pb?>?His-Cd???His-Pb?>?Thr-Cd?>?Thr-Pb?>?Phe-Cd???Phe-Pb???Asp-Cd???Asp-Pb???Met-Cd???Met-Pb???Glu-Cd???Glu-Pb?>?Ser-Cd???Ser-Pb. The effects of amino acid concentration and stability constants of amino acid-metal complexes are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1559-0720
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-85
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Chromatography and atomic absorption spectrometry for the assessment of heavy metal distribution among amino acids used in parenteral nutrition formulations-studies with cadmium and lead.
pubmed:affiliation
Departamento de Química, Universidade Federal de Santa Maria, 97111-970, Santa Maria, RS, Brazil. pcn1954@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't