Linked Life Data

20496422

Source:http://linkedlifedata.com/resource/pubmed/id/20496422

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-27
pubmed:abstractText
The use of bone marrow-derived mesenchymal stem cells (MSCs) has shown promise in cell-based cartilage regeneration. A yet-unsolved problem, however, is the unwanted up-regulation of markers of hypertrophy, such as alkaline phosphatase (AP) and type X collagen, during in vitro chondrogenesis and the formation of unstable calcifying cartilage at heterotopic sites. In contrast, articular chondrocytes produce stable, nonmineralizing cartilage. The aim of this study was to address whether coculture of MSCs with human articular chondrocytes (HACs) can suppress the undesired hypertrophy in differentiating MSCs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1529-0131
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2696-706
pubmed:meshHeading
pubmed-meshheading:20496422-Animals, pubmed-meshheading:20496422-Bone Marrow Cells, pubmed-meshheading:20496422-Cartilage, Articular, pubmed-meshheading:20496422-Cell Differentiation, pubmed-meshheading:20496422-Cell Enlargement, pubmed-meshheading:20496422-Cells, Cultured, pubmed-meshheading:20496422-Chondrocytes, pubmed-meshheading:20496422-Chondrogenesis, pubmed-meshheading:20496422-Coculture Techniques, pubmed-meshheading:20496422-Collagen Type X, pubmed-meshheading:20496422-Culture Media, Conditioned, pubmed-meshheading:20496422-Fibroblast Growth Factor 2, pubmed-meshheading:20496422-Gene Expression, pubmed-meshheading:20496422-Hedgehog Proteins, pubmed-meshheading:20496422-Humans, pubmed-meshheading:20496422-Hypertrophy, pubmed-meshheading:20496422-Mesenchymal Stem Cells, pubmed-meshheading:20496422-Mice, pubmed-meshheading:20496422-Mice, SCID, pubmed-meshheading:20496422-Parathyroid Hormone-Related Protein, pubmed-meshheading:20496422-RNA, Messenger, pubmed-meshheading:20496422-Transforming Growth Factor beta, pubmed-meshheading:20496422-Transplantation, Heterotopic
pubmed:year
2010
pubmed:articleTitle
Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis.
pubmed:affiliation
Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't