rdf:type |
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lifeskim:mentions |
umls-concept:C0002932,
umls-concept:C0011155,
umls-concept:C0018549,
umls-concept:C0026809,
umls-concept:C0086045,
umls-concept:C0900627,
umls-concept:C1280500,
umls-concept:C1333226,
umls-concept:C1414064,
umls-concept:C1440080,
umls-concept:C1524031,
umls-concept:C1705335
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-27
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pubmed:abstractText |
The authors have previously shown that the clinically relevant concentrations of inhalational anesthetics dose-dependently inhibit the postsynaptic density protein (PSD)-95, Dlg, and ZO-1 domain-mediated protein interactions between N-methyl-d-aspartate receptors and PSD-95/synaptic-associated protein (SAP) 90 or PSD-93/Chapsyn-110 and that the knockdown of spinal PSD-95/SAP90 significantly reduces the minimum alveolar concentration (MAC) for isoflurane in rats.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, Antisense
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
1528-1175
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pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1444-51
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20460989-Anesthetics, Inhalation,
pubmed-meshheading:20460989-Animals,
pubmed-meshheading:20460989-Guanylate Kinase,
pubmed-meshheading:20460989-Halothane,
pubmed-meshheading:20460989-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20460989-Male,
pubmed-meshheading:20460989-Membrane Proteins,
pubmed-meshheading:20460989-Mice,
pubmed-meshheading:20460989-Mice, Inbred C57BL,
pubmed-meshheading:20460989-Mice, Knockout,
pubmed-meshheading:20460989-Motor Activity,
pubmed-meshheading:20460989-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:20460989-Pulmonary Alveoli
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pubmed:year |
2010
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pubmed:articleTitle |
Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in mice.
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pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|