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rdf:type |
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lifeskim:mentions |
umls-concept:C0015520,
umls-concept:C0017262,
umls-concept:C0040048,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0225336,
umls-concept:C0752312,
umls-concept:C1370600,
umls-concept:C1424650,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2011-7-12
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pubmed:abstractText |
Tissue factor (TF) is an initiator of coagulation. The serine protease factor Xa (FXa) is the convergence point of the extrinsic and intrinsic components of the coagulation cascade. In addition to its hemostatic function, FXa elicits inflammatory responses in endothelial cells that may be important in surgical procedures in which inflammation is triggered. This study tested the hypothesis that FXa can up-regulate TF on vascular endothelial cells by a mitogen-activated protein kinase (MAPK)- and NF-?B-dependent pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-methylphenylsulfonyl)-2-propene...,
http://linkedlifedata.com/resource/pubmed/chemical/Antithrombins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Factor Xa,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Hirudins,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboplastin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-27
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pubmed:meshHeading |
pubmed-meshheading:20451919-Antithrombins,
pubmed-meshheading:20451919-Cells, Cultured,
pubmed-meshheading:20451919-Chromones,
pubmed-meshheading:20451919-Endothelium, Vascular,
pubmed-meshheading:20451919-Factor Xa,
pubmed-meshheading:20451919-Flavonoids,
pubmed-meshheading:20451919-Hirudins,
pubmed-meshheading:20451919-Humans,
pubmed-meshheading:20451919-MAP Kinase Kinase 1,
pubmed-meshheading:20451919-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20451919-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20451919-Morpholines,
pubmed-meshheading:20451919-NF-kappa B,
pubmed-meshheading:20451919-Nitriles,
pubmed-meshheading:20451919-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20451919-Signal Transduction,
pubmed-meshheading:20451919-Sulfones,
pubmed-meshheading:20451919-Thrombin,
pubmed-meshheading:20451919-Thromboplastin,
pubmed-meshheading:20451919-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-?B-dependent pathways.
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pubmed:affiliation |
Cardiothoracic Research Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Georgia, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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