Source:http://linkedlifedata.com/resource/pubmed/id/20422754
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2010-4-27
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pubmed:abstractText |
In this 5-year prospective cohort study, 92 clinically healthy subjects (42 men and 50 women) were screened for G-308A polymorphism of the TNF-alpha gene. Fasting serum lipid levels and carotid intima-media thickness (IMT) were measured. Triglyceride levels in the GA+AA group were significantly (more than 3-fold) higher than in GG genotype patients. Patients in the former group had apolipoprotein index above 1 twice more frequently in the latter. The 5-year probability of atherosclerosis in GA+AA male patients was 55.9 +/- 15.4% vs. 9.1 +/- 6.1% in GG men (p < 0.001). The presence of A allele in TNFa gene was associated with a 9 times higher risk of early atherosclerosis estimated using the multivariate stepwise Cox regression model.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0869-6047
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3-6
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pubmed:meshHeading |
pubmed-meshheading:20422754-Adult,
pubmed-meshheading:20422754-Atherosclerosis,
pubmed-meshheading:20422754-Dyslipidemias,
pubmed-meshheading:20422754-Female,
pubmed-meshheading:20422754-Humans,
pubmed-meshheading:20422754-Male,
pubmed-meshheading:20422754-Middle Aged,
pubmed-meshheading:20422754-Multivariate Analysis,
pubmed-meshheading:20422754-Polymorphism, Genetic,
pubmed-meshheading:20422754-Prognosis,
pubmed-meshheading:20422754-Proportional Hazards Models,
pubmed-meshheading:20422754-Risk,
pubmed-meshheading:20422754-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
[Impact of TNF-alpha gene polymorphism, development of atherogenic dyslipidemia and risk of atherosclerosis].
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pubmed:publicationType |
Journal Article,
English Abstract
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