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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-11-11
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pubmed:abstractText |
The effective maturation of dendritic cells (DC) is complex and highly regulated and requires the presence of a variety of signals. Tumor necrosis factor (TNF) and its receptors or innate pattern recognition receptors such as the toll-like receptors have been shown to contribute to this process. DC derived from bone marrow cells in the presence of granulocyte/macrophage colony-stimulating factor can be used as a model to ascertain the contribution of different signals to DC maturation. Analysis of DC activated by addition of the mycobacterial vaccine strain Bacillus Calmette-Guérin showed that of the effector molecules studied only interleukin-10 expression was significantly reduced in TNF-negative (B6.TNF(-/-)) DC. Another effector molecule produced by DC, inducible nitric oxide synthase, was largely unchanged.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1440-1711
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-5
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pubmed:meshHeading |
pubmed-meshheading:20421877-Animals,
pubmed-meshheading:20421877-BCG Vaccine,
pubmed-meshheading:20421877-Bone Marrow,
pubmed-meshheading:20421877-Cell Differentiation,
pubmed-meshheading:20421877-Cells, Cultured,
pubmed-meshheading:20421877-Dendritic Cells,
pubmed-meshheading:20421877-Gene Expression Regulation,
pubmed-meshheading:20421877-Interleukin-10,
pubmed-meshheading:20421877-Mice,
pubmed-meshheading:20421877-Mice, Inbred C57BL,
pubmed-meshheading:20421877-Mice, Knockout,
pubmed-meshheading:20421877-Nitric Oxide,
pubmed-meshheading:20421877-Nitric Oxide Synthase,
pubmed-meshheading:20421877-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:20421877-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression.
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pubmed:affiliation |
Cellular Immunology Laboratory, Comparative Genomics Centre, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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