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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0025266,
umls-concept:C0040300,
umls-concept:C0185117,
umls-concept:C0221284,
umls-concept:C0227952,
umls-concept:C1136376,
umls-concept:C2346714,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-3
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pubmed:abstractText |
A biological explanation for the reduction in HIV-1 (HIV) acquisition after male circumcision may be that removal of the foreskin reduces the number of target cells for HIV. The expression of potential HIV target cells and C-type lectin receptors in foreskin tissue of men at risk of HIV infection were thus analyzed. Thirty-three foreskin tissue samples, stratified by Herpes simplex virus type 2 status, were obtained from a randomized, controlled trial conducted in Kenya. The samples were analyzed by confocal in situ imaging microscopy and mRNA quantification by quantitative RT-qPCR. The presence and location of T cells (CD3(+)CD4(+)), Langerhans cells (CD1a(+)Langerin/CD207(+)), macrophages (CD68(+) or CD14(+)), and submucosal dendritic cells (CD123(+)BDCA-2(+) or CD11c(+)DC-SIGN(+)) were defined. C-type lectin receptor expressing cells were detected in both the epithelium and submucosa, and distinct lymphoid aggregates densely populated with CD3(+)CD4(+) T cells were identified in the submucosa. Although the presence of lymphoid aggregates and mRNA expression of selected markers varied between study subjects, Herpes simplex virus type 2 serostatus was not the major determinant for the detected differences. The detection of abundant and superficially present potential HIV target cells and submucosal lymphoid aggregates in foreskin mucosa from a highly relevant HIV risk group demonstrate a possible anatomical explanation that may contribute to the protective effect of male circumcision on HIV transmission.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-10721995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-11846609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-12208964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-12213715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-12352970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-1434540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-14693841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-14991068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-15078900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-15709031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16093359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16231970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16322748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16613341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16847403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-16878046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-17306567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-17321310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-17321311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-17334373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-17442711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-18462586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-18670228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-18941170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19114867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19184514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19325114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19363450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19584700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-19648930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-2373685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20395432-7558138
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1525-2191
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2798-805
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20395432-Adolescent,
pubmed-meshheading:20395432-Biological Markers,
pubmed-meshheading:20395432-Clinical Trials as Topic,
pubmed-meshheading:20395432-Foreskin,
pubmed-meshheading:20395432-HIV Infections,
pubmed-meshheading:20395432-HIV-1,
pubmed-meshheading:20395432-Herpesvirus 2, Human,
pubmed-meshheading:20395432-Humans,
pubmed-meshheading:20395432-Kenya,
pubmed-meshheading:20395432-Lectins, C-Type,
pubmed-meshheading:20395432-Male,
pubmed-meshheading:20395432-T-Lymphocytes,
pubmed-meshheading:20395432-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men.
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pubmed:affiliation |
Center for Molecular Medicine, Infectious Disease Unit, Department of Medicine, Solna, Karolinska Institutet, 171 76 Stockholm, Sweden. taha.hirbod@ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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