| pubmed-article:20383584 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C1705325 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C1257975 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C0218504 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C1150481 | lld:lifeskim |
| pubmed-article:20383584 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:20383584 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20383584 | pubmed:dateCreated | 2010-12-2 | lld:pubmed |
| pubmed-article:20383584 | pubmed:abstractText | Bone marrow-derived mesenchymal stem cells (BMSCs) have been demonstrated to be a promising cell sources for cardiac regeneration. Poor survival rate of transplanted BMSCs in infarcted myocardium attenuated its clinical application. It's reported that stromal-derived factor-1 (SDF-1) could protect progenitor cells including endothelial progenitor cells and embryonic stem cells from apoptosis. But little is known whether SDF-1? protein has the same protective effects on BMSCs under conditions of hypoxia and serum deprivation (hypoxia/SD). In present study, we verified that SDF-1? (0.50-2.0 ?g/ml) inhibited hypoxia/SD induced apoptosis of BMSCs through mitochondrial pathway. After administration of SDF-1?, the loss of mitochondrial membrane potential and cytochrome c released from mitochondria to cytosol were significantly inhibited, and caspase 3 activity also declined. Furthermore, the effect of SDF-1? on mitochondrial pathway was neutralized by using PI3K inhibitor (Wortmannin) and ERK1/2 inhibitor (U0126). Our observations suggested that SDF-1? inhibits hypoxia/SD induced BMSCs apoptosis through PI3K/Akt and ERK1/2 signaling pathways. These data also imply that the anti-apoptotic effect mediated by SDF-1? may enhance cell survival after cell transplantation. | lld:pubmed |
| pubmed-article:20383584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20383584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20383584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20383584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20383584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20383584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20383584 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20383584 | pubmed:issn | 1573-4978 | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:ItôMM | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:RoeE JEJJr | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:WeiYingjieY | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:LiuXuebinX | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:YinQiQ | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:LinXiaomingX | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:JinPeifengP | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:ChiChuangC | lld:pubmed |
| pubmed-article:20383584 | pubmed:author | pubmed-author:SunChengchaoC | lld:pubmed |
| pubmed-article:20383584 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20383584 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:20383584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20383584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20383584 | pubmed:pagination | 9-16 | lld:pubmed |
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| pubmed-article:20383584 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20383584 | pubmed:articleTitle | SDF-1? inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways. | lld:pubmed |
| pubmed-article:20383584 | pubmed:affiliation | Research Center for Cardiac Regenerative Medicine, The Ministry of Health, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. | lld:pubmed |
| pubmed-article:20383584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20383584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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