Source:http://linkedlifedata.com/resource/umls/id/C0218504
MSH: A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.,NCI: Encoded by human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family), alternative alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1 are chemoattractant ligands for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional C-terminal sequence. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI)