Linked Life Data

20371488

Source:http://linkedlifedata.com/resource/pubmed/id/20371488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2010-4-7
pubmed:abstractText
A body of research has strongly implicated inflammation in the genesis of obesity-associated diseases such as type 2 diabetes and cardiovascular disease. An outstanding issue is how obesity-induced metabolic signals are translated into an inflammatory response. In this issue of Science Translational Medicine, Kishore et al. demonstrate that the action of free fatty acids on adipose tissue macrophages dynamically regulates the expression of plasminogen activator inhibitor-1, a serine protease inhibitor that suppresses the breakdown of blood clots. Their data suggest that these macrophages sit in a specialized microenvironment that senses metabolic signals from fat cells and the circulation and integrates them to produce an inflammatory signal.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1946-6242
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20ps7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Adipose tissue macrophages: a piece of the PAI of metabolic syndrome.
pubmed:affiliation
Department of Pediatrics and Communicable Diseases, and Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. clumeng@umich.edu
pubmed:publicationType
Journal Article, Comment