|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002716,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0030281,
umls-concept:C0035820,
umls-concept:C0086418,
umls-concept:C0291573,
umls-concept:C0600688,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C2003941
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-5-27
|
|
pubmed:abstractText |
Type 2 diabetes is characterised by decreased beta cell mass and islet amyloid formation. Islet amyloid formed by aggregation of human islet amyloid polypeptide (hIAPP) is associated with beta cell apoptosis. We used human and transgenic mouse islets in culture to examine whether deletion of caspase-3 protects islets from apoptosis induced by endogenously produced and exogenously applied hIAPP and compared hIAPP toxicity in islet alpha and beta cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1432-0428
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1415-27
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:20369225-Amyloid,
pubmed-meshheading:20369225-Animals,
pubmed-meshheading:20369225-Apoptosis,
pubmed-meshheading:20369225-Caspase 3,
pubmed-meshheading:20369225-Cell Line,
pubmed-meshheading:20369225-Cells, Cultured,
pubmed-meshheading:20369225-Diabetes Mellitus, Type 2,
pubmed-meshheading:20369225-Glucagon-Secreting Cells,
pubmed-meshheading:20369225-Humans,
pubmed-meshheading:20369225-In Situ Nick-End Labeling,
pubmed-meshheading:20369225-Insulin-Secreting Cells,
pubmed-meshheading:20369225-Islet Amyloid Polypeptide,
pubmed-meshheading:20369225-Islets of Langerhans,
pubmed-meshheading:20369225-Mice,
pubmed-meshheading:20369225-Mice, Knockout,
pubmed-meshheading:20369225-Rats
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3.
|
|
pubmed:affiliation |
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
