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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-4-1
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pubmed:abstractText |
Novel oligo(ethylene glycol)-based thermoresponsive stationary phases have been studied for the separation of bioanalytes. Well-defined copolymers of (2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate were synthesized by atom-transfer radical polymerization in the presence of an N-succinimidyl-functionalized initiator. The reactive chain ends of these copolymers were then reacted with amino-functionalized silica monoliths. The formed composites were studied as chromatography materials. For instance, it was demonstrated that thermoresponsive oligo(ethylene glycol)-based stationary phases allow rapid, efficient separation of steroid and protein mixtures in pure water under isocratic high-performance liquid chromatographic elution.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1944-8244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1869-72
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pubmed:meshHeading |
pubmed-meshheading:20355808-Acrylic Resins,
pubmed-meshheading:20355808-Biocompatible Materials,
pubmed-meshheading:20355808-Chemistry,
pubmed-meshheading:20355808-Chromatography, High Pressure Liquid,
pubmed-meshheading:20355808-Cortisone,
pubmed-meshheading:20355808-Materials Testing,
pubmed-meshheading:20355808-Models, Chemical,
pubmed-meshheading:20355808-Polyethylene Glycols,
pubmed-meshheading:20355808-Polymers,
pubmed-meshheading:20355808-Silicon Dioxide,
pubmed-meshheading:20355808-Surface Properties,
pubmed-meshheading:20355808-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
PEGylated Chromatography: Efficient Bioseparation on Silica Monoliths Grafted with Smart Biocompatible Polymers.
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pubmed:affiliation |
Colloid Chemistry Department, Max-Planck Institute of Colloids and Interfaces, Scientific Campus Golm, 14476 Potsdam, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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