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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-3-31
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pubmed:abstractText |
It was demonstrated in chronic experiments in Wistar rats that only the first of daily multiple microinjections of glutamate metabotropic 5-th type receptor antagonist MTEP into the rostral region of neostriatum impaired the avoidance conditioning in a shuttle box. Within the next two weeks, MTEP was ineffective but being injected into the neostriatum simultaneously with picrotoxin prevented the impairment of avoidance conditioning in a shuttle-box and decreased the hyperactivity (open-field locomotor hyperactivity and choreic hyperkinesis) produced by this GABA-A receptor antagonist. The results do not suggest the involvement of striatal glutamate metabotropic 5-th type receptors in avoidance conditioning control but demonstrate that glutamate metabotropic system is involved in behavioral disorders mediated by inhibition of GABA-A receptors. In principle, it might be possible to treat the human hyperkinetic basal ganglia dysfunction (Huntington's horea), athetosis and similar disorders with glutamate metabotropic receptor antagonists.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0044-4677
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-7
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pubmed:meshHeading |
pubmed-meshheading:20352688-Animals,
pubmed-meshheading:20352688-Conditioning, Classical,
pubmed-meshheading:20352688-Corpus Striatum,
pubmed-meshheading:20352688-Escape Reaction,
pubmed-meshheading:20352688-GABA Antagonists,
pubmed-meshheading:20352688-Humans,
pubmed-meshheading:20352688-Huntington Disease,
pubmed-meshheading:20352688-Hyperkinesis,
pubmed-meshheading:20352688-Locomotion,
pubmed-meshheading:20352688-Microinjections,
pubmed-meshheading:20352688-Neostriatum,
pubmed-meshheading:20352688-Picrotoxin,
pubmed-meshheading:20352688-Pyridines,
pubmed-meshheading:20352688-Rats,
pubmed-meshheading:20352688-Rats, Wistar,
pubmed-meshheading:20352688-Receptors, Metabotropic Glutamate,
pubmed-meshheading:20352688-Thiazoles
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pubmed:articleTitle |
[The blocade of glutamate metabotropic 5-th tipe receptors prevents the locomotor behavior changes produced by intrastriatal picrotoxin microinjections in rats].
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pubmed:publicationType |
Journal Article,
English Abstract
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