| pubmed-article:20350779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C0235974 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C1523298 | lld:lifeskim |
| pubmed-article:20350779 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:20350779 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20350779 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20350779 | pubmed:abstractText | The transcription factor NF-kappaB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF-kappaB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-kappaB signalling by non-destructible IkappaBalpha rendered cells resistant to TGF-beta-induced epithelial-mesenchymal transition (EMT). In contrast, NF-kappaB activation by TNF-alpha or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1, and down-regulation of E-cadherin. EMT could also be induced in cells with defective TGF-beta signalling. Functional assays demonstrated reduced or strongly enhanced migration and invasion upon NF-kappaB inhibition or activation, respectively. | lld:pubmed |
| pubmed-article:20350779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20350779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20350779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20350779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20350779 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20350779 | pubmed:issn | 1872-7980 | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:HuberMargit... | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:WirthThomasT | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:BeugHartmutH | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:MaierHarald... | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:Schmidt-Stras... | lld:pubmed |
| pubmed-article:20350779 | pubmed:author | pubmed-author:WiedemannEva... | lld:pubmed |
| pubmed-article:20350779 | pubmed:copyrightInfo | 2010 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20350779 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20350779 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:20350779 | pubmed:volume | 295 | lld:pubmed |
| pubmed-article:20350779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20350779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20350779 | pubmed:pagination | 214-28 | lld:pubmed |
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| pubmed-article:20350779 | pubmed:meshHeading | pubmed-meshheading:20350779... | lld:pubmed |
| pubmed-article:20350779 | pubmed:meshHeading | pubmed-meshheading:20350779... | lld:pubmed |
| pubmed-article:20350779 | pubmed:meshHeading | pubmed-meshheading:20350779... | lld:pubmed |
| pubmed-article:20350779 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20350779 | pubmed:articleTitle | NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. | lld:pubmed |
| pubmed-article:20350779 | pubmed:affiliation | Institute of Physiological Chemistry, University of Ulm, Germany. | lld:pubmed |
| pubmed-article:20350779 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20350779 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4790 | entrezgene:pubmed | pubmed-article:20350779 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20350779 | lld:pubmed |
