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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
The transcription factor NF-kappaB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF-kappaB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-kappaB signalling by non-destructible IkappaBalpha rendered cells resistant to TGF-beta-induced epithelial-mesenchymal transition (EMT). In contrast, NF-kappaB activation by TNF-alpha or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1, and down-regulation of E-cadherin. EMT could also be induced in cells with defective TGF-beta signalling. Functional assays demonstrated reduced or strongly enhanced migration and invasion upon NF-kappaB inhibition or activation, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1872-7980
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
214-28
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pubmed:meshHeading |
pubmed-meshheading:20350779-Cell Line, Tumor,
pubmed-meshheading:20350779-Cell Movement,
pubmed-meshheading:20350779-Epithelial Cells,
pubmed-meshheading:20350779-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:20350779-Homeodomain Proteins,
pubmed-meshheading:20350779-Humans,
pubmed-meshheading:20350779-MAP Kinase Signaling System,
pubmed-meshheading:20350779-Matrix Metalloproteinases,
pubmed-meshheading:20350779-Mesoderm,
pubmed-meshheading:20350779-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:20350779-NF-kappa B,
pubmed-meshheading:20350779-Neoplasm Invasiveness,
pubmed-meshheading:20350779-Pancreatic Neoplasms,
pubmed-meshheading:20350779-Transcription Factors,
pubmed-meshheading:20350779-Transforming Growth Factor beta,
pubmed-meshheading:20350779-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells.
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pubmed:affiliation |
Institute of Physiological Chemistry, University of Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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