Linked Life Data

20348156

Source:http://linkedlifedata.com/resource/pubmed/id/20348156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-11-11
pubmed:abstractText
Cortical spreading depression (CSD) is an electrophysiological phenomenon first described by Leao in 1944 as a suppression of spontaneous electroencephalographic activity, traveling across the cerebral cortex. In vitro studies suggest that CSD may induce synaptic potentiation. One recent study also found that CSD is followed by a non-rapid eye movement (NREM) sleep duration increase, suggesting an increased need for sleep. Recent experiments in animals and humans show that the occurrence of synaptic potentiation increases subsequent sleep need as measured by larger slow wave activity (SWA) during NREM sleep, prompting the question whether CSD can affect NREM SWA. Here, we find that, in freely moving rats, local CSD induction increases corticocortical evoked responses and strongly induces brain derived neurotrophic factor (BDNF) in the affected cortical hemisphere but not in the contralateral one, consistent with synaptic potentiation in vivo. Moreover, for several hours after CSD, large slow waves occur in the affected hemisphere during rapid eye movement sleep and quiet waking but disappear during active exploration. Finally, we find that CSD increases NREM sleep duration and SWA, the latter specifically in the affected hemisphere. These effects are consistent with an increase in synaptic strength triggered by CSD, although nonphysiological phenomena associated with CSD may also play a role.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000579-01, http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000579-02, http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000579-03, http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000579-04, http://linkedlifedata.com/resource/pubmed/grant/DP1 OD000579-05, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-01A1, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-01A10001, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-02, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-020001, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-03, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-030001, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-04, http://linkedlifedata.com/resource/pubmed/grant/P20 MH077967-040001
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1460-2199
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2939-47
pubmed:dateRevised
2011-6-14
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Unilateral cortical spreading depression affects sleep need and induces molecular and electrophysiological signs of synaptic potentiation in vivo.
pubmed:affiliation
Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison WI 53719, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural