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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Clodronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/Dendrimers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose-Binding Lectin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-2916
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pubmed:author |
pubmed-author:CarrollMichael CMC,
pubmed-author:CloningerMary JMJ,
pubmed-author:DegnSøren ESE,
pubmed-author:GonzalezSantiago FSF,
pubmed-author:GordonSiamonS,
pubmed-author:KimYoung-AYA,
pubmed-author:KuligowskiMichael PMP,
pubmed-author:Lukacs-KornekVeronikaV,
pubmed-author:Martinez-PomaresLuisaL,
pubmed-author:PitcherLisa ALA,
pubmed-author:TurleyShannon JSJ
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-34
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pubmed:meshHeading |
pubmed-meshheading:20305659-Animals,
pubmed-meshheading:20305659-Antibodies, Viral,
pubmed-meshheading:20305659-Antigen Presentation,
pubmed-meshheading:20305659-Cell Adhesion Molecules,
pubmed-meshheading:20305659-Cell Movement,
pubmed-meshheading:20305659-Cells, Cultured,
pubmed-meshheading:20305659-Clodronic Acid,
pubmed-meshheading:20305659-Dendrimers,
pubmed-meshheading:20305659-Dendritic Cells,
pubmed-meshheading:20305659-Endocytosis,
pubmed-meshheading:20305659-Immunity, Humoral,
pubmed-meshheading:20305659-Immunoglobulin Heavy Chains,
pubmed-meshheading:20305659-Immunotherapy, Active,
pubmed-meshheading:20305659-Influenza A virus,
pubmed-meshheading:20305659-Influenza Vaccines,
pubmed-meshheading:20305659-Lectins, C-Type,
pubmed-meshheading:20305659-Lymph Nodes,
pubmed-meshheading:20305659-Macrophages,
pubmed-meshheading:20305659-Mannose-Binding Lectin,
pubmed-meshheading:20305659-Mice,
pubmed-meshheading:20305659-Mice, Knockout,
pubmed-meshheading:20305659-Mice, Transgenic,
pubmed-meshheading:20305659-Microscopy, Fluorescence, Multiphoton,
pubmed-meshheading:20305659-Orthomyxoviridae Infections,
pubmed-meshheading:20305659-Receptors, Cell Surface
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pubmed:year |
2010
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pubmed:articleTitle |
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.
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pubmed:affiliation |
The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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