Linked Life Data

20300599

Source:http://linkedlifedata.com/resource/pubmed/id/20300599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-3-19
pubmed:abstractText
Polyarteritis nodosa (PAN) is a systemic vasculitis whose severe forms are treated with glucocorticoids and cyclophosphamide. Refractory patients are exposed to many complications, notably accelerated atherosclerosis. We report a case report of 71-year-old man followed for polyarteritis nodosa refractory to glucocorticoids and cyclosphosphamide. Systemic vasculitis relapses are followed to accelerated atherosclerosis: severe ischemic lesions led to amputation of lower limbs. Remission of refractory PAN is obtained with rituximab. Disappearance of biological inflammatory is allowed to regression of ischemic lesions in upper limbs. In this situation, we recommend a systematic vascular work-up for patients suffered from refractory vasculitis. On the other hand, therapeutic trials are needed to determine the real efficacy and place of rituximab in the treatment of polyarteritis nodosa.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-10805482, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-12209502, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-15374854, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-15604904, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-15641078, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-15843671, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-16439439, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-16940394, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-18446015, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-19535611, http://linkedlifedata.com/resource/pubmed/commentcorrection/20300599-9048514
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1687-9635
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2009
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
738293
pubmed:year
2009
pubmed:articleTitle
Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare.
pubmed:affiliation
Service de Médecine Interne, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
pubmed:publicationType
Journal Article