Linked Life Data

20224174

Source:http://linkedlifedata.com/resource/pubmed/id/20224174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-12
pubmed:abstractText
The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1881-7122
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-103
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Global imaging of mitochondrial morphology in tissues using transgenic mice expressing mitochondrially targeted enhanced green fluorescent protein.
pubmed:affiliation
Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't