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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-5-29
|
| pubmed:abstractText |
Acute and chronic effects of epilepsy on endocrine function are known to occur in humans with partial seizures of limbic origin and in animals with limbic kindled seizures. The amygdala, a component of the limbic system, has dense hypothalamic connections and amygdala stimulation in monkeys and cats result in vasopressin release. In the present study we sought to determine if amygdala stimulation in the rats results in an immediate acute release of vasopressin and to determine if acute or chronic changes occur in vasopressin release in the fully kindled animal. Plasma vasopressin, osmolality and hematocrit were measured in blood samples drawn from rats with implanted venous catheters before and after stimulation and at different stages of kindling. Low-frequency (15 Hz) electrical stimulation of the amygdala was followed by an immediate, 3-fold increase in plasma vasopressin concentration. Moreover, although the 60 Hz kindling stimulus did not result in a significant immediate rise in plasma vasopressin prior to kindling, after kindling to stage 5 seizures the 60 Hz kindling stimulus resulted in seizures and a significant immediate rise in plasma vasopressin. In addition, we found that kindling was followed by a significant, though modest, rise in the resting plasma vasopressin without an accompanying change in osmolality or hematocrit. We conclude that kindling results in a persistent alteration in the vasopressinergic neuroendocrine system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
538
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
9-14
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2018936-Amygdala,
pubmed-meshheading:2018936-Animals,
pubmed-meshheading:2018936-Electric Stimulation,
pubmed-meshheading:2018936-Hematocrit,
pubmed-meshheading:2018936-Kindling, Neurologic,
pubmed-meshheading:2018936-Male,
pubmed-meshheading:2018936-Rats,
pubmed-meshheading:2018936-Rats, Inbred Strains,
pubmed-meshheading:2018936-Seizures,
pubmed-meshheading:2018936-Vasopressins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Amygdala kindling elevates plasma vasopressin.
|
| pubmed:affiliation |
Department of Neurology and Curriculum of Neurobiology, School of Medicine, University of North Carolina, Chapel Hill 27599-7025.
|
| pubmed:publicationType |
Journal Article
|