Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-10
pubmed:abstractText
Cyclooxygenase-2 (COX-2) is an important mediator of inflammation in stress and disease states. Recent attention has focused on the role of COX-2 in human heart failure and diseases owing to the finding that highly specific COX-2 inhibitors (i.e., Vioxx) increased the risk of myocardial infarction and stroke in chronic users. However, the specific impact of COX-2 expression in the intact heart remains to be determined. We report here the development of a transgenic mouse model, using a loxP-Cre approach, which displays robust COX-2 overexpression and subsequent prostaglandin synthesis specifically in ventricular myocytes. Histological, functional, and molecular analyses showed that ventricular myocyte specific COX-2 overexpression led to cardiac hypertrophy and fetal gene marker activation, but with preserved cardiac function. Therefore, specific induction of COX-2 and prostaglandin in vivo is sufficient to induce compensated hypertrophy and molecular remodeling.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-10966456, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-11087881, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-12702643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-15604124, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-15626689, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16043646, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16107267, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16339832, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16499924, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16505099, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16604526, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-1660837, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-16951323, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-17210840, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-17516164, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-17577107, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-18045153, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-18220723, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-18611916, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-19084534, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-6208643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-8557648, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-9314845, http://linkedlifedata.com/resource/pubmed/commentcorrection/20170663-9422794
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1095-8584
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-94
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
pubmed:affiliation
Department of Anesthesiology, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA 90095, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural