Linked Life Data

20148759

Source:http://linkedlifedata.com/resource/pubmed/id/20148759

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-12
pubmed:abstractText
Diverse neuronal cell types arise from the lateral neuroblast in the antennal lobe of Drosophila. The authors show that loss of Notch function from the entire lineage during development leads to an absence of local interneurons (LNs) with a concomitant increase in the number of projection neurons (PNs). The presence of the intracellular domain of Notch was observed within the nucleus of newly born neurons within the neuroblast lineage. This leads to the suggestion that Notch acts in a binary fate decision to determine formation of LNs and PNs, resulting in two distinct hemilineages from the single neuroblast. The observation of nuclear Notch in several neuroblast lineages leads us to speculate that this mechanism is widespread during the developing Drosophila brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1563-5260
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-53
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Notch regulates the generation of diverse cell types from the lateral lineage of Drosophila antennal lobe.
pubmed:affiliation
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't