| pubmed-article:20112075 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0014653 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0533670 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0540511 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20112075 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20112075 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20112075 | pubmed:dateCreated | 2010-5-25 | lld:pubmed |
| pubmed-article:20112075 | pubmed:abstractText | Sonic hedgehog (Shh) is a typical morphogen to regulate epithelial-mesenchymal interactions during embryonic development. Shh is also an indirect angiogenic agent upregulating other angiogenic factors, including angiopoietin-1 (Ang-1). Recent studies revealed that angiogenesis induced by Shh is characterized by distinct large-diameter vessels with less branching. Ang-1 promotes blood vessel maturation, and angiopoietin-2 (Ang-2) counteracts Ang-1 activity and regulates vascular branching. Thus, we hypothesized that Shh-induced angiogenesis is affected by expression of Ang-1 and Ang-2, and we investigated the regulatory system of angiopoietins by Shh in vitro. Shh enhanced Ang-1 expression but did not enhance vascular endothelial growth factor in fibroblasts. The upregulation of Ang-1 expression by Shh was significantly decreased by fibroblast growth factor-2 (FGF-2), a potent angiogenic factor. Furthermore, FGF-2 increased the expression of Ang-2 in endothelial cells. These findings suggest that Shh and FGF-2 regulate the expression balance of vascular morphogens Ang-1 and Ang-2 and are involved in angiogenesis. | lld:pubmed |
| pubmed-article:20112075 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20112075 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20112075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20112075 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20112075 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20112075 | pubmed:issn | 1543-706X | lld:pubmed |
| pubmed-article:20112075 | pubmed:author | pubmed-author:KuwanoHiroyuk... | lld:pubmed |
| pubmed-article:20112075 | pubmed:author | pubmed-author:FujiiTakaakiT | lld:pubmed |
| pubmed-article:20112075 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20112075 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:20112075 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20112075 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20112075 | pubmed:pagination | 487-91 | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:meshHeading | pubmed-meshheading:20112075... | lld:pubmed |
| pubmed-article:20112075 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20112075 | pubmed:articleTitle | Regulation of the expression balance of angiopoietin-1 and angiopoietin-2 by Shh and FGF-2. | lld:pubmed |
| pubmed-article:20112075 | pubmed:affiliation | Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. ftakaaki@med.gunma-u.ac.jp | lld:pubmed |
| pubmed-article:20112075 | pubmed:publicationType | Journal Article | lld:pubmed |
