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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-4-21
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pubmed:abstractText |
Tumor necrosis factor-alpha inducing protein (Tipalpha) is a unique carcinogenic factor released from Helicobacter pylori (H. pylori). Tipalpha specifically binds to cells and is incorporated into cytosol and nucleus, where it strongly induces expression of TNF-alpha and chemokine genes mediated through NF-kappaB activation, resulting in tumor development. To elucidate mechanism of action of Tipalpha, we studied a binding protein of Tipalpha in gastric epithelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tipalpha protein, Helicobacter...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/nucleolin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1432-1335
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
911-21
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pubmed:meshHeading |
pubmed-meshheading:20049476-Amino Acid Sequence,
pubmed-meshheading:20049476-Animals,
pubmed-meshheading:20049476-Bacterial Proteins,
pubmed-meshheading:20049476-Blotting, Western,
pubmed-meshheading:20049476-Carcinogens,
pubmed-meshheading:20049476-Chromatography, Liquid,
pubmed-meshheading:20049476-Down-Regulation,
pubmed-meshheading:20049476-Epithelial Cells,
pubmed-meshheading:20049476-Flow Cytometry,
pubmed-meshheading:20049476-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20049476-Immunoprecipitation,
pubmed-meshheading:20049476-Mass Spectrometry,
pubmed-meshheading:20049476-Mice,
pubmed-meshheading:20049476-Molecular Sequence Data,
pubmed-meshheading:20049476-NF-kappa B,
pubmed-meshheading:20049476-Phosphoproteins,
pubmed-meshheading:20049476-RNA-Binding Proteins,
pubmed-meshheading:20049476-Receptors, Cell Surface,
pubmed-meshheading:20049476-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20049476-Stomach Neoplasms,
pubmed-meshheading:20049476-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori.
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pubmed:affiliation |
Saitama Cancer Center, Research Institute for Clinical Oncology, Kitaadachi-gun, Saitama 362-0806, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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