Source:http://linkedlifedata.com/resource/pubmed/id/20020510
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-2-11
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| pubmed:abstractText |
In addition to the classical TH1 and TH2 cytokines, members of the recently identified IL-17 cytokine family play an important role in regulating cellular and humoral immune responses. At present nothing is known about the role of these cytokines in atherosclerosis. Expression of IL-17A, -E and -F was investigated in atherosclerotic tissue by rtPCR and immunohistochemistry. IL-17E and its receptor were further studied in cultured smooth muscle cells and endothelial cells, using rtPCR and western blot. rtPCR showed that IL-17A, -E and -F were expressed in the majority of plaques under investigation. IL-17A/F was expressed by mast cells in all stages of plaque development. IL-17A/F(+) neutrophils were always observed in complicated plaques, but hardly in intact lesions. IL-17A/F(+) Tcells ('TH17') were never observed. IL-17E was expressed by smooth muscle cells and endothelial cells in both normal and atherosclerotic arteries, and in advanced plaques also extensively by mature B cells. Cultured smooth muscle cells and endothelial cells were found to express both IL-17E and its functional receptor (IL-17RB). The constitutive expression of IL-17E by resident plaque cells, and the additional presence of IL-17E(+) B cells and IL-17A/F(+) neutrophils in advanced and complicated plaques indicates a complex contribution of IL-17 family cytokines in human atherosclerosis, depending on the stage and activity of the disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/IL17RB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1096-9896
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
220
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
499-508
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| pubmed:meshHeading |
pubmed-meshheading:20020510-Aged,
pubmed-meshheading:20020510-Aged, 80 and over,
pubmed-meshheading:20020510-Atherosclerosis,
pubmed-meshheading:20020510-Blotting, Western,
pubmed-meshheading:20020510-Cells, Cultured,
pubmed-meshheading:20020510-Endothelial Cells,
pubmed-meshheading:20020510-Endothelium, Vascular,
pubmed-meshheading:20020510-Gene Expression,
pubmed-meshheading:20020510-Humans,
pubmed-meshheading:20020510-Inflammation Mediators,
pubmed-meshheading:20020510-Interleukin-17,
pubmed-meshheading:20020510-Middle Aged,
pubmed-meshheading:20020510-Muscle, Smooth, Vascular,
pubmed-meshheading:20020510-Plasma Cells,
pubmed-meshheading:20020510-RNA, Messenger,
pubmed-meshheading:20020510-Receptors, Interleukin,
pubmed-meshheading:20020510-Reverse Transcriptase Polymerase Chain Reaction
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| pubmed:year |
2010
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| pubmed:articleTitle |
Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques.
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| pubmed:affiliation |
Department of Pathology, Academic Medical Centre, University of Amsterdam, The Netherlands. o.j.deboer@amc.uva.nl
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| pubmed:publicationType |
Journal Article
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