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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 3
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pubmed:dateCreated |
2010-3-4
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pubmed:abstractText |
The Dictyostelium Galpha5 subunit has been shown to reduce cell viability, inhibit folate chemotaxis and accelerate tip morphogenesis and gene expression during multicellular development. Alteration of the D-motif (mitogen-activated protein kinase docking site) at the amino terminus of the Galpha 5 subunit or the loss of extracellular signal-regulated kinase (ERK)1 diminished the lethality associated with the overexpression or constitutive activation of the Galpha5 subunit. The amino-terminal D-motif of the Galpha5 subunit was also found to be necessary for the reduced cell size, small aggregate formation and precocious developmental gene expression associated with Galpha5 subunit overexpression. This D-motif also contributed to the aggregation delay in cells expressing a constitutively active Galpha5 subunit, but the D-motif was not necessary for the inhibition of folate chemotaxis. These results suggest that the amino-terminal D-motif is required for some but not all phenotypes associated with elevated Galpha5 subunit functions during growth and development and that ERK1 can function in Galpha5 subunit-mediated signal transduction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20019085-10545250,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20019085-9779985
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1465-2080
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
789-97
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20019085-Amino Acid Motifs,
pubmed-meshheading:20019085-Amino Acid Sequence,
pubmed-meshheading:20019085-Chemotaxis,
pubmed-meshheading:20019085-Dictyostelium,
pubmed-meshheading:20019085-Folic Acid,
pubmed-meshheading:20019085-GTP-Binding Protein alpha Subunits,
pubmed-meshheading:20019085-Gene Expression Regulation, Developmental,
pubmed-meshheading:20019085-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20019085-Mitogen-Activated Protein Kinases,
pubmed-meshheading:20019085-Molecular Sequence Data,
pubmed-meshheading:20019085-Protozoan Proteins,
pubmed-meshheading:20019085-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
G{alpha}5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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