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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-2-15
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pubmed:abstractText |
Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35+/-7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-2518
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pubmed:author |
pubmed-author:BakerSherrylS,
pubmed-author:BojarskasJurgisJ,
pubmed-author:Borja-TaboraCharissa FayCF,
pubmed-author:BowonkiratikachornPiyapornP,
pubmed-author:BreimanRobert FRF,
pubmed-author:BrooksW AbdullahWA,
pubmed-author:ChaSunghoS,
pubmed-author:ChayOh MohOM,
pubmed-author:ChengSheau-MeiSM,
pubmed-author:CzajkaHannaH,
pubmed-author:ForrestBruce DBD,
pubmed-author:GruberWilliam CWC,
pubmed-author:Gutierrez-BritoMaricruzM,
pubmed-author:KaltenisPetrasP,
pubmed-author:LauYu-LungYL,
pubmed-author:LeeBee WahBW,
pubmed-author:LumLucy Chai SeeLC,
pubmed-author:PejczJerzyJ,
pubmed-author:RappaportRuthR,
pubmed-author:SablanBenjamin PBP,
pubmed-author:SchmittHeinz-JosefHJ,
pubmed-author:TamJohn SJS,
pubmed-author:TanKah KeeKK,
pubmed-author:TantracheewathornTaweewongT,
pubmed-author:VertruyenAndreA,
pubmed-author:VesikariTimoT
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pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1566-74
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pubmed:meshHeading |
pubmed-meshheading:20003918-Administration, Intranasal,
pubmed-meshheading:20003918-Antibodies, Viral,
pubmed-meshheading:20003918-Drug Incompatibility,
pubmed-meshheading:20003918-Female,
pubmed-meshheading:20003918-Humans,
pubmed-meshheading:20003918-Infant,
pubmed-meshheading:20003918-Influenza, Human,
pubmed-meshheading:20003918-Influenza Vaccines,
pubmed-meshheading:20003918-Male,
pubmed-meshheading:20003918-Measles,
pubmed-meshheading:20003918-Measles-Mumps-Rubella Vaccine,
pubmed-meshheading:20003918-Mumps,
pubmed-meshheading:20003918-Placebos,
pubmed-meshheading:20003918-Rubella,
pubmed-meshheading:20003918-Vaccination,
pubmed-meshheading:20003918-Vaccines, Attenuated,
pubmed-meshheading:20003918-Vaccines, Combined
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pubmed:year |
2010
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pubmed:articleTitle |
Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children.
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pubmed:affiliation |
Department of Pediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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